PHD2 deficiency refers to a condition where an individual has a deficiency in the enzyme prolyl hydroxylase domain protein 2 (PHD2). This enzyme plays a crucial role in regulating the levels of hypoxia-inducible factor (HIF), which is involved in the cellular response to low oxygen levels. Research on PHD2 deficiency focuses on understanding how this deficiency affects various physiological processes, such as oxygen sensing, angiogenesis, and metabolism, and how it may contribute to the development of diseases like cancer, cardiovascular disorders, and metabolic disorders. Studying PHD2 deficiency can provide insights into potential therapeutic targets for these diseases.